??

????????1?310????????????????????????????????????????????????

???????????????????????????

????(1)??????????(2)??????(3)?????(4)???????(5)???(6)?????????


? ????rhBMP-2???? ??9????????rhBMP-2??????X?????????? ???X??24??? ???rhBMP-2????

???????????????t?????????????????????????20012?20056???9????(nano-.hydroxyapatitenano-.HA)??????????


1 ?


1.1 ? 92?7921??13.3??5??2???2???????2????1??524??16?


1.2 ???????1.0 mm????rhBMP-2?????rhBMP-2?????????


1.3 ? ?X?????????????????????r...