???

?
????(Osteogenesis imperfecatOI)???(fragilitas
ossium)VanDerHeeve??-????45/10?60%????15%20%???25%???1??????????????????????????????2030?????????????-?????????????????????515??????????????????????X????????
??????????4?()?????????a1(1)???mRNA??????2()?10%????????????????????????a1(1)????a???????3()???????20%???????????5????
?a2(1)???a1(1)????4()??????????????a2N-??1520??a2(1)?4?????X???????????????????????????????????????????CD????????????????